α-Conotoxin PIA

α-Conotoxin PIA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets nAChR subtypes containing α6 and α3 subunits. α-Conotoxin PIA has the potential for the research of Parkinson’s disease, and schizophrenia[1]。

O=C1N2[C@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@H](C(N)=O)CSSC[C@@]3(NC(=O)[C@@H](NC(=O)[C@H]4N(C([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CC(O)=O)=O)CCC4)CSSC[C@@](C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H]([C@H](C)C)C(=O)N[C@@H](CC5=CN=CN5)C(=O)N[C@H]1CC(N)=O)[H])(NC(=O)[C@H]([C@H](C)C)NC(=O)[C@]6(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC3=O)CCC6)[H])[H])[H])[H])(CCC2)[H]

[1]Seung-Wook Chi, et al. Solution Structure of Alpha-Conotoxin PIA, a Novel Antagonist of alpha6 Subunit Containing Nicotinic Acetylcholine Receptors. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1990-7.