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Bethanidine (sulfate)

Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects[1].

Product Specifications

CAS Number

[114-85-2]

Product Name Alternative

BW 467C60

UNSPSC

12352211

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bethanidine-sulfate.html

Smiles

O=S(O)(O)=O.CN/C(NC)=N/CC1=CC=CC=C1.[0.5]

Molecular Formula

C10H17N3O4S

Molecular Weight

275.32

References & Citations

[1]ADRENERGIC NEURONE BLOCKADE AND OTHER ACUTE EFFECTS CAUSED BY N-BENZYL-N′N″-DIMETHYLGUANIDINE* AND ITS ORTHO-CHLORO DERIVATIVE

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Curated Selection

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