MAGL-IN-3
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50=34.1 nM) . It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.
Product Specifications
CAS Number
2514-37-6
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/magl-in-3.html
Smiles
O=C1N(CCC2=CC=CC=C2)SC3=C1C=CC=C3
Molecular Formula
C15H13NOS
Molecular Weight
255.33
References & Citations
[1]Castelli, et al. Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines. J. Med. Chem. 63 (3), 1261-1280 (2020) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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