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MAGL-IN-3

CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50=34.1 nM) . It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.

Product Specifications

CAS Number

2514-37-6

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/magl-in-3.html

Smiles

O=C1N(CCC2=CC=CC=C2)SC3=C1C=CC=C3

Molecular Formula

C15H13NOS

Molecular Weight

255.33

References & Citations

[1]Castelli, et al. Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines. J. Med. Chem. 63 (3), 1261-1280 (2020) .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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