Pomiferin
Product Specifications
UNSPSC Description
Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM).
Target Antigen
HDAC; mTOR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pomiferin.html
Purity
98.98
Solubility
DMSO : 8.5 mg/mL (ultrasonic;warming)
Smiles
O=C1C2=C(O)C(C/C=C(C)\C)=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C(O)=C4
Molecular Weight
420.45
References & Citations
[1]Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5.|[2]Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21.|[3]Bartošíková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3(2):76-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N4315/Pomiferin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N4315/Pomiferin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
572-03-2
Available Sizes
Curated Selection
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