Pomiferin

Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM) .

Product Specifications

CAS Number

[572-03-2]

Product Name Alternative

NSC 5113

UNSPSC

12352005

Target

HDAC; mTOR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pomiferin.html

Purity

98.98

Solubility

DMSO : 8.5 mg/mL (ultrasonic; warming)

Smiles

O=C1C2=C(O)C(C/C=C(C)\C)=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C(O)=C4

Molecular Formula

C25H24O6

Molecular Weight

420.45

References & Citations

[1]Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17 (17) :4753-5.|[2]Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88 (3) :313-21.|[3]Bartošíková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3 (2) :76-81.