Pomiferin
Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM) .
Product Specifications
CAS Number
[572-03-2]
Product Name Alternative
NSC 5113
UNSPSC
12352005
Target
HDAC; mTOR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pomiferin.html
Purity
98.98
Solubility
DMSO : 8.5 mg/mL (ultrasonic; warming)
Smiles
O=C1C2=C(O)C(C/C=C(C)\C)=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C(O)=C4
Molecular Formula
C25H24O6
Molecular Weight
420.45
References & Citations
[1]Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17 (17) :4753-5.|[2]Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88 (3) :313-21.|[3]Bartošíková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3 (2) :76-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HDAC; mTOR
Available Sizes
Curated Selection
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