DMH-1 (GMP)
DMH-1 (GMP) is a GMP-grade version of DMH-1. Small molecules of GMP grade can be used as adjuvant reagents in cell therapy. DMH-1 (GMP) promotes cardiac differentiation in mouse embryonic stem cells. DMH-1 (GMP) promotes neurogenesis of hiPSCs. DMH-1 is a potent and selective BMP inhibitor[1][2].
Product Specifications
CAS Number
1206711-16-1
UNSPSC
12352005
Hazard Statement
H301
Target
Autophagy; TGF-β Receptor
Type
Reference compound
Related Pathways
Autophagy; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmh-1-gmp.html
Smiles
CC(C)OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1
Molecular Formula
C24H20N4O
Molecular Weight
380.44
Precautions
H301
References & Citations
[1]Neely MD, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci. 2012 Jun 20;3 (6) :482-91.|[2]Ao A, et al. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PLoS One. 2012;7 (7) :e41627.
Shipping Conditions
Blue Ice
Storage Conditions
Keep sealed and protect from light, store at 2-8°C
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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