Clorgyline

Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases[1].

Product Specifications

CAS Number

[17780-72-2]

Product Name Alternative

M&B 9302

UNSPSC

12352005

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/clorgyline.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C(Cl)=C1)OCCCN(CC#C)C

Molecular Formula

C13H15Cl2NO

Molecular Weight

272.17

References & Citations

[1]Knoll J. The possible mechanisms of action of (-) deprenyl in Parkinson's disease[J]. Journal of Neural Transmission, 1978, 43: 177-198.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Chembiochem. 2025 Oct 28:e202500462.|Biochem Biophys Res Commun. 2022 May 28;606:135-141.|Cell Rep. 2022 Dec 13;41 (11) :111827.|FASEB J. 2021 Jun;35 (6) :e21652.|Immunomedicine. 2022 Dec;2 (2) :e1041.|J Immunother Cancer. 2025 Mar 22;13 (3) :e010555.|Sci Total Environ. 2023 Dec 15:904:166688.