MICA, Human (HEK293, His-Avi)

MHC class I chain-related protein A (MICA) is a highly polymorphic major histocompatability complex class I chain-related protein A. MICA is expressed on the cell surface and is a ligand for the NKG2-D type II integral membrane protein receptor and functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, MICA has been associated with susceptibility to psoriasis 1 and psoriatic arthritis. MICA Protein, Human (HEK293, His-Avi) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Product Specifications

Product Name Alternative

MICA Protein, Human (HEK293, His-Avi), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/mica-protein-human-hek293-his-avi.html

Molecular Formula

100507436 (Gene_ID) Q96QC4 (E24-Q308) (Accession)

Molecular Weight

Approximately 55-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Jeevankumar S, et al. Association of MICA gene Exon-5 polymorphism in oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Jan;135 (1) :110-116.|[2]Tchacrome I, et al. Diseases association with the polymorphic major histocompatibility complex class I related chain a: MICA gene. Transpl Immunol. 2022 Dec;75:101665.