TR antagonist 1
TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
Product Specifications
CAS Number
[500794-88-7]
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/_E_-3--3,5-Dibromo-4--4-hydroxy-3-isopropyl-5-_2-_pyridin-4-yl_ethenyl_phenoxy-phenyl-propionic_acid.html
Purity
99.49
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CCC1=CC(Br)=C(OC2=CC(/C=C/C3=CC=NC=C3)=C(O)C(C(C)C)=C2)C(Br)=C1
Molecular Formula
C25H23Br2NO4
Molecular Weight
561.26
References & Citations
[1]Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49 (23) :6635-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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