(1R,2R) -ML-SI3

(1R,2R) -ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R) -ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively[1].

Product Specifications

CAS Number

[2418594-00-8]

Product Name Alternative

(-) -trans-ML-SI3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1r-2r-ml-si3.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=CC=C1N2CCN([C@@H]3CCCC[C@H]3NS(C4=CC=CC=C4)(=O)=O)CC2

Molecular Formula

C23H31N3O3S

Molecular Weight

429.58

Precautions

H302, H315, H319

References & Citations

[1]Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966.