(1R,2R) -ML-SI3
(1R,2R) -ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R) -ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively[1].
Product Specifications
CAS Number
[2418594-00-8]
Product Name Alternative
(-) -trans-ML-SI3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/1r-2r-ml-si3.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=CC=C1N2CCN([C@@H]3CCCC[C@H]3NS(C4=CC=CC=C4)(=O)=O)CC2
Molecular Formula
C23H31N3O3S
Molecular Weight
429.58
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPML1; TRPML2; TRPML3
Available Sizes
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