Walrycin B
Walrycin B, an analogue of toxoflavin, is a potent SARS-CoV-2 3CLpro inhibitor with an IC50 of 0.26 μM. Walrycin B is a WalR response regulator inhibitor. Walrycin B has potent activity of inhibiting bacteria growth[1][2].
Product Specifications
CAS Number
878419-78-4
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Antibiotic; Bacterial; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/walrycin-b.html
Purity
98.11
Solubility
DMSO : 11.5 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=NC(C2=CC=C(C(F)(F)F)C=C2)=NN(C)C1=N3)N(C)C3=O
Molecular Formula
C14H10F3N5O2
Molecular Weight
337.26
Precautions
H302, H315, H320, H335
References & Citations
[1]Gotoh Y, et al. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo) . 2010 Mar;63 (3) :127-34.|[2]Wei Zhu, et al. Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening. bioRxiv. 2020 Aug 11:2020.07.17.207019.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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