(Rac)-Bedaquiline
Product Specifications
UNSPSC Description
(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[1][2].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rac-bedaquiline.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=C(N=C(OC)C(C(C(CCN(C)C)(O)C2=CC=CC3=C2C=CC=C3)C4=CC=CC=C4)=C5)C5=C1
Molecular Weight
555.50
References & Citations
[1]Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Jun;55(6):483-487. |[2]Sarathy JP, et al. TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14881B/Rac-Bedaquiline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14881B/
Clinical Information
No Development Reported
CAS Number
654655-80-8
Available Sizes
Curated Selection
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