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(Rac) -Bedaquiline

(Rac) -Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[1][2].

Product Specifications

CAS Number

654655-80-8

Product Name Alternative

(Rac) -TMC207; (Rac) -R207910

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/rac-bedaquiline.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C(N=C(OC)C(C(C(CCN(C)C)(O)C2=CC=CC3=C2C=CC=C3)C4=CC=CC=C4)=C5)C5=C1

Molecular Formula

C32H31BrN2O2

Molecular Weight

555.50

References & Citations

[1]Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Jun;55 (6) :483-487. |[2]Sarathy JP, et al. TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 Jan 27;64 (2) :e01540-19.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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