Naproxen
Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
Product Specifications
CAS Number
22204-53-1
Product Name Alternative
(S) -Naproxen
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H361, H402, H411
Target
Autophagy; COX
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Naproxen.html
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL|H2O : 75 mg/mL (ultrasonic; warming)
Smiles
C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
Molecular Formula
C14H14O3
Molecular Weight
230.26
Precautions
H302, H315, H319, H335, H361, H402, H411
References & Citations
[1]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90 (24) :11693-7.|[2]Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351 (2) :308-16.|[3]Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2
Available Sizes
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