WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally active WRN inhibitor with anticancer activity. WRN inhibitor 14 results in tumor growth inhibition in the SW48 xenograft model in BALB/c nude mice[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-14.html
Smiles
O=C1C(N2CCN(CC2)C(C3=NC=NC(C)=C3O)=O)=C(N(C4=NC(N5CCC6(CCCCO6)CC5)=NN41)CC(NC7=CC=C(C=C7F)C(F)(F)F)=O)CC
Molecular Formula
C35H40F4N10O5
Molecular Weight
756.75
References & Citations
[1]Sui Q, et al. Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors. Eur J Med Chem. 2025 Jan 15;282:117039.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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