GW409544
GW409544 is a potent PPARα and PPARγ activator, with EC50 values of 2.3 nM and 0.28 nM for PPARα and PPARγ, respectively. GW409544 can be used for the research of metabolic and cardiovascular diseases[1].
Product Specifications
CAS Number
[258345-41-4]
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gw409544.html
Smiles
O=C(C1=CC=CC=C1)/C=C(C)\N[C@H](C(O)=O)CC(C=C2)=CC=C2OCCC3=C(C)OC(C4=CC=CC=C4)=N3
Molecular Formula
C31H30N2O5
Molecular Weight
510.58
References & Citations
[1]Xu HE, et al. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 2001 Nov 20;98 (24) :13919-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PPARα; PPARγ
Curated Selection
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