IGF1
Recombinant Human Insulin-like Growth Factor I (4-70) is produced by our E.coli expression system and the target gene encoding Thr52-Ala118 is expressed.
Product Specifications
Background
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.
Synonyms
Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; mgF; Somatomedin-C; IGF1; IBP1
Expression System
E. Coli
Endotoxin
Less than 0.05 ng/ µg (0.5 IEU/ µg) as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Form
Lyophilized
Shipping Conditions
The product is shipped at ambient temperature.
Formulation
Lyophilized from a 0.2 μm filtered solution of 300mM NaAc, pH 6.5.
Species
Human
Shipping Temperature
Ambient
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