Human Recombinant CD4 Extracellular Domain

<strong>Human Recombinant CD4 Extracellular Domain </strong>_x000D_ <strong>Catalog number:</strong> B2017039_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 67.4 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Cluster of Differentiation 4, T Cell Surface Antigen T4, T Cell Surface Glycoprotein CD4_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Lee BC, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance Biochim Biophys Acta. 2014 Mar;1842(3):446-62._x000D_ 2: Gratton S, Haughn L, Sekaly RP, Julius M. The extracellular domain of CD4 regulates the initiation of T cell activation Mol Immunol. 2000 Apr;37(5):213-9._x000D_ 3: Lenert P, Kroon D, Spiegelberg H, Golub ES, Zanetti M. Human CD4 binds immunoglobulins Science. 1990 Jun 29;248(4963):1639-43._x000D_ 4: Raja NU, Jabbar MA. The human immunodeficiency virus type 1 Vpu protein tethered to the CD4 extracellular domain is localized to the plasma membrane and is biologically active in the secretory pathway of mammalian cells: implications for the mechanisms of Vpu function Virology. 1996 Jun 1;220(1):141-51._x000D_ 5: Chang H, Smallwood PM, Williams J, Nathans J. Intramembrane Proteolysis of Astrotactins J Biol Chem. 2017 Feb 24;292(8):3506-3516._x000D_ 6: Anderson SJ, Lenburg M, Landau NR, Garcia JV. The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef J Virol. 1994 May;68(5):3092-101._x000D_ 7: Jin Q, Agrawal L, VanHorn-Ali Z, Alkhatib G. Infection of CD4+ T lymphocytes by the human T cell leukemia virus type 1 is mediated by the glucose transporter GLUT-1: evidence using antibodies specific to the receptor's large extracellular domain Virology. 2006 May 25;349(1):184-96._x000D_ 8: Rechter M, Lider O, Cahalon L, Baharav E, Dekel M, Seigel D, Vlodavsky I, Aingorn H, Cohen IR, Shoseyov O. A cellulose-binding domain-fused recombinant human T cell connective tissue-activating peptide-III manifests heparanase activity Biochem Biophys Res Commun. 1999 Feb 24;255(3):657-62._x000D_ 9: Secchiero P, Sun D, De Vico AL, Crowley RW, Reitz MS Jr, Zauli G, Lusso P, Gallo RC. Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans J Virol. 1997 Jun;71(6):4571-80._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/12695117">10: Nakamura K, Yube K, Miyatake A, Cambier JC, Hirashima M. Involvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation Mol Immunol. 2003 May;39(15):909-21. </a>_x000D_ _x000D_ <strong>Products Related to Human Recombinant CD4 Extracellular Domain can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>