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Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1)

Selected Variant

HY-P990304-01

Size: 1 mg

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4+ and CD8+ T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK) [1][2][3][4][5].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

TNF Receptor

Type

Inhibitory Antibodies

Related Pathways

Apoptosis

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-4-1bbl-cd137l-antibody-tks-1.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

[Anti-Mouse4-1BBL/CD137LAntibody(TKS-1)]

Molecular Weight

(150 kDa)

References & Citations

[1]Welten SP, et al. The viral context instructs the redundancy of costimulatory pathways in driving CD8 (+) T cell expansion. Elife. 2015 Aug 11;4:e07486.|[2]Seo SK, et al. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol. 2003 Jul 15;171 (2) :576-83.|[3]Cho HR, et al. Blockade of 4-1BB (CD137) /4-1BB ligand interactions increases allograft survival. Transpl Int. 2004 Aug;17 (7) :351-61.|[4]Miki H, et al. 4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis. J Immunol. 2020 Apr 1;204 (7) :1892-1903.|[5]Cho E, et al. 4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8+ T cell. Cell Mol Immunol. 2023 Sep;20 (9) :1077-1080.

Shipping Conditions

Isolate blue ice and the product with bubble pack to avoid direct contact

Storage Conditions

Store at 4°C, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

Price

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