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Loureirin B (Standard)

Loureirin B (Standard) is the analytical standard of Loureirin B. This product is intended for research and analytical applications. Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

Product Specifications

CAS Number

119425-90-0

UNSPSC

12352005

Target

ERK; JNK; PAI-1; Potassium Channel; Reference Standards

Type

Reference Standards

Related Pathways

MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/loureirin-b-standard.html

Smiles

O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(OC)C=C2OC

Molecular Formula

C18H20O5

Molecular Weight

316.35

References & Citations

[1]Sha Y, et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17.|[2]He T, et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37 (2) :666-76.|[3]Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24 (5) :355-60.|[4]Yu Jiang, et al. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evidence-Based Complementary and Alternative Medicine

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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