Human GLP1R Protein, His Tag, low Endotoxin (MALS verified)

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) . Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.6 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P43220-1

Expression Region

Ala 21 - Glu 139

Host

HEK293

Target

GLP1R

Conjugation

Unconjugated

Tag

C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.01 EU per μg

Purity

90%

Bioactivity

Immobilized Human GLP1R Protein, His Tag (Cat. No. GLR-H52H7) at 2 μg/mL (100 μL/well) can bind Mouse Monoclonal GLP-1R Antibody with a linear range of 0.2-4 ng/mL (QC tested).