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Lobeline (hydrochloride) (Standard)

Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride) . This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation[1][2].

Product Specifications

CAS Number

134-63-4

Product Name Alternative

α-Lobeline (hydrochloride) (Standard) ; L-Lobeline (hydrochloride) (Standard)

UNSPSC

12352005

Target

Dopamine Transporter; nAChR; Reference Standards

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lobeline-hydrochloride-standard.html

Smiles

CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.[H]Cl

Molecular Formula

C22H28ClNO2

Molecular Weight

373.92

References & Citations

[1]Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280 (3) :1432-44. |[2]Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70.|[3]Harrod SB, et al. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul;298 (1) :172-9.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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