(+) -Penbutolol

(+) -Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+) -Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].

Product Specifications

CAS Number

[38363-41-6]

Product Name Alternative

(R) -Penbutolol; (+) -Isopenbutolol

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/__addition__-Penbutolol.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](COC1=C(C=CC=C1)C2CCCC2)CNC(C)(C)C

Molecular Formula

C18H29NO2

Molecular Weight

291.43

References & Citations

[1]Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca (2+) -overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118 (4) :865-70.|[2]Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271 (1) :1-8.