PNPS-DHA

PNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC50 of 15 μM[1].

Product Specifications

CAS Number

[2454246-25-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pnps-dha.html

Solubility

10 mM in DMSO

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NS(=O)(C1=CC=C([N+]([O-])=O)C=C1)=O)=O

Molecular Formula

C28H36N2O5S

Molecular Weight

512.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kim IH, et al. Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo. J Med Chem. 2019 Nov 14;62 (21) :9576-9592.