Ficellomycin

Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases[1].

Product Specifications

CAS Number

[59458-27-4]

Product Name Alternative

U-47929

UNSPSC

12352005

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ficellomycin.html

Smiles

[H][C@]1(C[C@@H]([C@@H]2CN21)NC(N)=N)C(C(O)=O)NC([C@H](C(C)C)N)=O

Molecular Formula

C13H24N6O3

Molecular Weight

312.37

References & Citations

[1]He X, et al. Ficellomycin: an aziridine alkaloid antibiotic with potential therapeutic capacity. Appl Microbiol Biotechnol. 2018 May;102 (10) :4345-4354.