Aminoguanidine

Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142) . Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research[1][2][3][4].

Product Specifications

CAS Number

[79-17-4]

Product Name Alternative

Pimagedine; GER-11 (free base) ; Aminoguanidinium

UNSPSC

12352211

Hazard Statement

H228-H315-H318-H335

Target

Apoptosis; NO Synthase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/aminoguanidine.html

Smiles

N=C(NN)N

Molecular Formula

CH6N4

Molecular Weight

74.09

Precautions

P210-P240-P241-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P370+P378-P403+P233-P405-P501

References & Citations

[1]Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394 (1-2) :129-35.|[2]Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47 (5) :572-580. PMID: 29066484.|[3]Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66 (3) :265-70.|[4]Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16 (1) :8-14.