MGD-4
MGD-4 is an orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].
Product Specifications
CAS Number
2991817-99-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKZF Family
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mgd-4.html
Purity
95.86
Smiles
O=C1N(C2C(NC(CC2)=O)=O)N(C)CC3=C(N)C=CC=C31
Molecular Formula
C14H16N4O3
Molecular Weight
288.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF1; IKZF2; IKZF3
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