MGD-4

MGD-4 is an orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].

Product Specifications

CAS Number

[2991817-99-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IKZF Family

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mgd-4.html

Purity

95.86

Smiles

O=C1N(C2C(NC(CC2)=O)=O)N(C)CC3=C(N)C=CC=C31

Molecular Formula

C14H16N4O3

Molecular Weight

288.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.