KRAS G12D inhibitor 1
KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC50 of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer[1].
Product Specifications
CAS Number
[2621928-43-4]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12d-inhibitor-1.html
Purity
98.45
Smiles
OC1=CC(C2=C(F)C3=NC(OC[C@@]45CCCN4C[C@H](F)C5)=NC(N6C[C@H]7N[C@H](CC7)C6)=C3C=N2)=C8C(C#C)=CC=CC8=C1
Molecular Formula
C33H32F2N6O2
Molecular Weight
582.64
References & Citations
[1]WANG XIAOLUN (US), et al. KRAS G12D INHIBITORS. WO2021041671.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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