Ophiobolin C
Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells[1]. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells[2].
Product Specifications
CAS Number
19022-51-6
Product Name Alternative
Zizanin A
UNSPSC
12352211
Target
CCR; HIV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ophiobolin-c.html
Solubility
10 mM in DMSO
Smiles
O=C/C1=C/C[C@]([C@@H]([C@@H](C)CC/C=C(C)\C)CC2)([H])[C@@]2(C)C[C@@]([C@](C)(O)C3)([H])[C@]1([H])C3=O
Molecular Formula
C25H38O3
Molecular Weight
386.57
References & Citations
[1]Jayasuriya H, et al. Isolation and structure of antagonists of chemokine receptor (CCR5) . J Nat Prod. 2004 Jun;67 (6) :1036-8. |[2]Bladt TT, et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules. 2013 Nov 26;18 (12) :14629-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR5; HIV-1
Frequently Asked Questions
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