Ophiobolin C

Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells[1]. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells[2].

Product Specifications

CAS Number

[19022-51-6]

Product Name Alternative

Zizanin A

UNSPSC

12352211

Target

CCR; HIV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ophiobolin-c.html

Solubility

10 mM in DMSO

Smiles

O=C/C1=C/C[C@]([C@@H]([C@@H](C)CC/C=C(C)\C)CC2)([H])[C@@]2(C)C[C@@]([C@](C)(O)C3)([H])[C@]1([H])C3=O

Molecular Formula

C25H38O3

Molecular Weight

386.57

References & Citations

[1]Jayasuriya H, et al. Isolation and structure of antagonists of chemokine receptor (CCR5) . J Nat Prod. 2004 Jun;67 (6) :1036-8. |[2]Bladt TT, et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules. 2013 Nov 26;18 (12) :14629-50.