EIF4EBP1 antibody
Product Specifications
Background
Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), is a member of 4EBPs family, which regulate the translation of a subset of mRNA by competing with eIF4G for binding to eIF4E, thus preventing the assembly of the eIF4F complex. The eIF4F facilitates the recruitment of other translation initiation factors to form the complex and then initiates cap-dependent translation.4EBP1 also mediates the regulation of protein translation by growth factors, hormones and other stimuli that signal through the MAP kinase and mTORC1 pathways. There are three forms of 4EBP1, alpha, beta and gamma.
Synonyms
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1, eIF4E-binding protein 1) |Phosphorylated heat- and acid-stable protein regulated by insulin 1 (PHAS-I) |EIF4EBP1
Gene ID
1978
UniProt
Q13541
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Eukaryotic translation initiation factor 4E binding protein 1
Target
EIF4EBP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
17 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
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