SMARCA4 antibody

SMARCA4, also named as BAF190A, BRG1, SNF2B and SNF2L4, belongs to the SNF2/RAD54 helicase family. SMARCA4 is a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It is a component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. It is also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Transcription activator BRG1|ATP-dependent helicase SMARCA4|BRG1-associated factor 190A (BAF190A) |Mitotic growth and transcription activator|Protein BRG-1|Protein brahma homolog 1|SNF2-beta|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4|SMARCA4|BAF190A|BRG1|SNF2B|SNF2L4