SMARCA4 antibody
Product Specifications
Background
SMARCA4, also named as BAF190A, BRG1, SNF2B and SNF2L4, belongs to the SNF2/RAD54 helicase family. SMARCA4 is a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It is a component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. It is also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
Synonyms
Transcription activator BRG1|ATP-dependent helicase SMARCA4|BRG1-associated factor 190A (BAF190A) |Mitotic growth and transcription activator|Protein BRG-1|Protein brahma homolog 1|SNF2-beta|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4|SMARCA4|BAF190A|BRG1|SNF2B|SNF2L4
Gene ID
6597
UniProt
P51532
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Target
SMARCA4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Stem Cells, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
185 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
555-762aa
Curated Selection
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