CASP1 antibody
Product Specifications
Background
CASP1 (caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020) . It has 5 isoforms produced by alternative splicing.
Synonyms
Caspase-1 (CASP-1) |Interleukin-1 beta convertase (IL-1BC) |Interleukin-1 beta-converting enzyme (ICE, IL-1 beta-converting enzyme) |p45|Caspase-1 subunit p20|Caspase-1 subunit p10|CASP1|IL1BC|IL1BCE
Gene ID
834
UniProt
P29466
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Caspase 1
Target
CASP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45-47 kDa, 30 kDa, 35 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-311aa
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