VEGFA antibody
Product Specifications
Background
VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010). This antibody can recognize all the isoforms of VEFGA.
Synonyms
Vascular endothelial growth factor A, long form (L-VEGF)|Vascular permeability factor (VPF)|N-VEGF|VEGFA|VEGFA|VEGF
UniProt
P15692
Host
Mouse
Reactivity
Human
Immunogen
vascular endothelial growth factor A
Target
VEGFA
Clonality
Monoclonal
Isotype
IgG2b
Clone
5H5
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Cardiovascular, Cancer, Immunology, Developmental biology
Purification
protein A+G purified
Dilution
WB: 1:1000-1:4000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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