SOCS1 antibody

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Suppressor of cytokine signaling 1 (SOCS-1) |JAK-binding protein (JAB) |STAT-induced STAT inhibitor 1 (SSI-1) |Tec-interacting protein 3 (TIP-3) |SOCS1|SSI1|TIP3