SNCA antibody
Product Specifications
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Synonyms
Alpha-synuclein|Non-A beta component of AD amyloid|Non-A4 component of amyloid precursor (NACP) |SNCA|NACP|PARK1
Gene ID
6622
UniProt
P37840
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Synuclein, alpha (non A4 component of amyloid precursor)
Target
SNCA
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, IHC, WB
Field of Research
Neuroscience
Purification
Protein A+G purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
18 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
5C6
Tested Applications
ELISA, IHC, WB
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