ATP7B antibody
Product Specifications
Background
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Synonyms
Copper-transporting ATPase 2|Copper pump 2|Wilson disease-associated protein|WND/140 kDa|ATP7B|PWD|WC1|WND
Gene ID
540
UniProt
P35670
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
ATP7B
Target
ATP7B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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