NAMPT antibody
Product Specifications
Background
Nicotinamide phosphoribosyltransferase (NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.
Synonyms
Nicotinamide phosphoribosyltransferase (NAmPRTase, Nampt) |Pre-B-cell colony-enhancing factor 1 (Pre-B cell-enhancing factor) |Visfatin|NAMPT|PBEF|PBEF1
Gene ID
10135
UniProt
P43490
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Nicotinamide phosphoribosyltransferase
Target
NAMPT
Clonality
Monoclonal
Isotype
IgG2b
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Immunology, Signal Transduction, Metabolism, Cardiovascular
Purification
Protein A+G purified
Dilution
WB: 1:1000-1:4000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
52 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
2G6
Tested Applications
ELISA, WB, IHC, IF
Curated Selection
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