TNFSF11 antibody

TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.

Tumor necrosis factor ligand superfamily member 11|Osteoclast differentiation factor (ODF)|Osteoprotegerin ligand (OPGL)|Receptor activator of nuclear factor kappa-B ligand (RANKL)|TNF-related activation-induced cytokine (TRANCE)|Tumor necrosis factor ligand superfamily member 11, membrane form|Tumor necrosis factor ligand superfamily member 11, soluble form|TNFSF11|OPGL|RANKL|TRANCE