TLR4 antibody

Product Specifications

Background

TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS) . TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Synonyms

Toll-like receptor 4|hToll|TLR4

Gene ID

7099

UniProt

O00206

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Toll-like receptor 4

Target

TLR4

Clonality

Monoclonal

Isotype

IgG2b

Applications

ELISA, WB, IHC

Field of Research

Neuroscience, Immunology, Signal Transduction, Developmental biology

Purification

Protein A+G purification

Dilution

WB: 1:1000-1:8000; IHC: 1:50-1:500

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

100 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Clone ID

3E7

Tested Applications

ELISA, WB, IHC

Immunogen Sequence

650-839aa

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