TLR4 antibody
Product Specifications
Background
TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS) . TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Synonyms
Toll-like receptor 4|hToll|TLR4
Gene ID
7099
UniProt
O00206
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Toll-like receptor 4
Target
TLR4
Clonality
Monoclonal
Isotype
IgG2b
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Immunology, Signal Transduction, Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:8000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
3E7
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
650-839aa
Curated Selection
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