FHIT antibody
Product Specifications
Background
This gene, a member of the histidine triad gene family, encodes a diadenosine 5', 5'''-P1, P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
Synonyms
Bis(5'-adenosyl)-triphosphatase|AP3A hydrolase (AP3Aase)|Adenosine 5'-monophosphoramidase FHIT|Adenylylsulfatase|Adenylylsulfate-ammonia adenylyltransferase|Diadenosine 5',5'''-P1,P3-triphosphate hydrolase|Dinucleosidetriphosphatase|Fragile histidine triad protein|FHIT
Gene ID
2272
UniProt
P49789
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
FHIT
Target
FHIT
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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