ZRANB3 antibody
Product Specifications
Background
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Synonyms
DNA annealing helicase and endonuclease ZRANB3|Annealing helicase 2 (AH2) |Zinc finger Ran-binding domain-containing protein 3|ZRANB3
Gene ID
84083
UniProt
Q5FWF4
Host
Rabbit
Reactivity
Human
Immunogen
Zinc finger, RAN-binding domain containing 3
Target
ZRANB3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa and 50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
