Maduramicin (ammonium)

Maduramicin (Maduramycin) ammonium is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium is an oral active anticoccidial agent used in research related to Eimeria, Adenosarcina, Enterococcus faecalis, and Enterococcus disperitus infections. Maduramicin ammonium induces apoptosis (apoptosis) in chicken cardiomyocytes through both intrinsic and extrinsic pathways and also impairs autophagic flux and induces rhabdomyolysis by activating the AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway[1][2][3][4].

Product Specifications

CAS Number

[84878-61-5]

Product Name Alternative

Maduramycin (ammonium)

UNSPSC

12352005

Hazard Statement

H301

Target

AMPK; Antibiotic; Apoptosis; Autophagy; Bacterial; Eukaryotic Initiation Factor (eIF)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/maduramicin-ammonium.html

Purity

99.89

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@]1([C@]2([H])O[C@](C)([C@@]3([H])[C@H](C[C@@]([C@@]4([H])O[C@](O)([C@H](C)C[C@@H]4C)C)([H])O3)O[C@]5([H])C[C@@H]([C@@H](OC)[C@H](C)O5)OC)CC2)O[C@]6(O[C@]([C@H](C)[C@@H](O)C6)([H])[C@H]([C@@]7([H])[C@@H]([C@H]([C@H](C)[C@](CC(O)=O)(O)O7)OC)OC)C)CC1.N

Molecular Formula

C47H83NO17

Molecular Weight

934.16

Precautions

H301

References & Citations

[1]McDougald LR, et al. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.Avian Dis. 1990 Jul-Sep;34 (3) :634-8.|[2]Gao X, et al.Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicol In Vitro. 2018 Aug;50:190-200.|[3]Gao X, et al. Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model. Int J Environ Res Public Health. 2020 Oct 27;17 (21) :7882.|[4]Chen X, et al. Maduramicin ammonium impairs autophagic flux through activating AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway in skeletal muscle. J Sci Food Agric. 2024 Dec 11.