ZGPAT antibody
Product Specifications
Background
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
Synonyms
Zinc finger CCCH-type with G patch domain-containing protein|G patch domain-containing protein 6|Zinc finger CCCH domain-containing protein 9|Zinc finger and G patch domain-containing protein|ZGPAT|GPATC6|GPATCH6|KIAA1847|ZC3H9|ZC3HDC9|ZIP
Gene ID
84619
UniProt
Q8N5A5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Zinc finger, CCCH-type with G patch domain
Target
ZGPAT
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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