ZFYVE19 antibody
Product Specifications
Background
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Synonyms
Abscission/NoCut checkpoint regulator (ANCHR) |MLL partner containing FYVE domain|Zinc finger FYVE domain-containing protein 19|ZFYVE19|ANCHR|MPFYVE
Gene ID
84936
UniProt
Q96K21
Host
Rabbit
Reactivity
Human
Immunogen
Zinc finger, FYVE domain containing 19
Target
ZFYVE19
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:10000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
52 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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