ZFP36L2 antibody

MRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510) . Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity) .

MRNA decay activator protein ZFP36L2|Butyrate response factor 2|EGF-response factor 2 (ERF-2) |TPA-induced sequence 11d|Zinc finger protein 36, C3H1 type-like 2 (ZFP36-like 2) |ZFP36L2|ERF2|RNF162C|TIS11D